SARS-OMICs
Multi-Omics atlas of the Brazilian COVID-19
About the project
COVID-19 is a respiratory syndrome which was declared world pandemic in March 2020. The worst pandemic in the last 100 years. The disease is caused by severe acute respiratory syndrome coronavirus 2, also known as SARS-CoV-2. Symptoms of COVID-19 are variable, but often include fever, cough, fatigue, breathing difficulties, and loss of smell and taste. While most people have mild symptoms, some people develop acute and severe reactions, which may lead to ICU admission and death. Until now, factors that lead to different symptoms are not totally known, possibly being a mixture of host and viral genetic factors.
This project aims to perform an extensive characterization of the microbial community in respiratory samples of patients with COVID-19. To achieve this goal, several omics approaches will be used, such as 16S/ITS microbial sequencing, shotgun metagenomics, RNA virome, and target SARS-CoV-2 sequencing.
By applying aforementioned approaches, we expect to generate data which will help the scientific community to understand how microbial composition and genetic factors may influence the outcomes of the disease. In total, 600 samples obtained by a partnership between Brazilian Health Ministry and Hospital ALbert Einstein will be included in this study.
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The people involved
Who are the people making the project happen.
João Renato Rebello Pinho
Medical Coordinator - Clinical Laboratory of Hospital Israelita Albert Einstein
Principal researcher and responsible for the project
Murilo Castro Cervato
CEO Varstation and Manager of Data Science and Bioinformatics at Hospital Israelita Albert Einstein.
Responsible for the management and integration of the project's multidisciplinary team
Tatiana Ferreira de Almeida
Médica Geneticista do Laboratório Clínico do Hospital Albert Einstein
Responsável pela coalizão de projetos com COVID19 e pelo Biobanco de amostras
Deyvid Amgarten
Bioinformatician at Hospital Israelita Albert Einstein
Responsible for the development of bioinformatics analysis related to viral genomics and metagenomics.
Fernanda de Mello Malta
Sr. Laboratory Analyst at Hospital Israelita Albert Einstein
Responsible for the laboratory team and next generation sequencing (NGS).
Raquel Riyuzo
Bioinformatician at Hospital Israelita Albert Einstein
Responsible for the development of bioinformatics analysis related to microbiome and metagenomics.
Ana Paula Moreira Salles
Jr Laboratory Analyst at Hospital Israelita Albert Einstein
Responsible for New Generation Sequencing (NGS).
Pedro Henrique Sebe Rodrigues
Data Scientist at Hospital Israelita Albert Einstein
Responsible for statistical analysis and data mining.
Leandro Navatta Ribeiro
Programmer
Responsible for managing and developing systems for the project.
Ana Laura Boechat Borges
PhD Biochemistry
Responsible for new generation sequencing (NGS).
Maiara Prado Garcia Antonio
B.Sc Biomedical Sciences
Responsible for new generation sequencing (NGS).
Ketti Gleyzer De Oliveira
Research Assistant at Hospital Albert Einstein
Responsible for managing processes related to clinical research
Ricardo Andreotti Siqueira
Research Assistant at Hospital Albert Einstein
Responsible for managing processes related to clinical research
Gabriela Borges Cherulli Colichio
Research Assistant at Hospital Albert Einstein
Responsible for managing processes related to clinical research
Beatriz Miranda
Student in Biomedical Informatics
Responsible for statistical analysis and data mining.
Rafael da Silva Barbosa
Studying Marketing Technical Teaching
Responsible for social media.
Partner organizations
